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Properties of the amniotic membrane for potential use in tissue engineering
Thursday, 22 March 1398 00:00Niknejad H1, Peirovi H, Jorjani M, Ahmadiani A, Ghanavi J, Seifalian AM
Abstract
An important component of tissue engineering (TE) is the supporting matrix upon which cells and tissues grow, also known as the scaffold. Scaffolds must easily integrate with host tissue and provide an excellent environment for cell growth and differentiation.
The Mechanism of Cell Interaction and Response on Decellularized Human Amniotic Membrane: Implications in Wound Healing
Monday, 03 April 2017 07:28Bhatia M , Pereira M , Rana H , Stout B , Lewis C , Abramson S , Labazzo K , Ray C , Liu Q , Hofgartner W , Hariri R
Abstract
ACELAGRAFT™ (Celgene Cellular Therapeutics, Cedar Knolls, NJ) was developed as a decellularized and dehydrated human amniotic membrane product (DDHAM). The product has demonstrated potential as a wound healing product with several ongoing preclinical and clinical studies in the area of acute and chronic ulcers.
Scientific and clinical support for the use of dehydrated amniotic membrane in wound management
Monday, 03 April 2017 07:27Fetterolf DE , Snyder RJ
Abstract
Amniotic membrane has been employed in the treatment of wounds for almost 100 years, beginning with early application of natural amniotic membrane obtained from labor and delivery to various types of burns and wounds.
Treatment of chronic diabetic lower extremity ulcers with advanced therapies: a prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost
Monday, 03 April 2017 07:26Charles M Zelen, Thomas E Serena, Lisa Gould, Lam Le, Marissa J Carter, Jennifer Keller & William W Li
Abstract
Advanced therapies such as bioengineered skin substitutes (BSS) and dehydrated human amnion/chorion membrane (dHACM) have been shown to promote healing of chronic diabetic ulcers. An interim analysis of data from 60 patients enrolled in a prospective, randomised, controlled, parallel group, multi-centre clinical trial showed that dHACM (EpiFix®, MiMedx Group Inc., Marietta, GA) is superior to standard wound care (SWC) and BSS (Apligraf®, Organogenesis, Inc., Canton, MA) in achieving complete wound closure within 4–6 weeks.
Case report of non-healing surgical wound treated with dehydrated human amniotic membrane
Thursday, 22 March 1398 00:00Neil H Riordan, Ben A George , Troy B Chandler and Randall W McKenna
Abstract
Introduction:
Non-healing wounds can pose a medical challenge as in the case of vasculopathic venostasis resulting in a surgical ulcer. When traditional approaches to wound care fail, an amniotic patch (a dehydrated tissue allograft derived from human amnion) can function as a biologic scaffold to facilitate and enhance tissue regeneration and rehabilitation.
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