Niknejad H1, Peirovi H, Jorjani M, Ahmadiani A, Ghanavi J, Seifalian AM

Abstract

An important component of tissue engineering (TE) is the supporting matrix upon which cells and tissues grow, also known as the scaffold. Scaffolds must easily integrate with host tissue and provide an excellent environment for cell growth and differentiation. 

Bhatia M , Pereira M , Rana H , Stout B , Lewis C , Abramson S , Labazzo K , Ray C , Liu Q , Hofgartner W , Hariri R  
 

Abstract

ACELAGRAFT™ (Celgene Cellular Therapeutics, Cedar Knolls, NJ) was developed as a decellularized and dehydrated human amniotic membrane product (DDHAM). The product has demonstrated potential as a wound healing product with several ongoing preclinical and clinical studies in the area of acute and chronic ulcers.

Fetterolf DE , Snyder RJ

Abstract

 Amniotic membrane has been employed in the treatment of wounds for almost 100 years, beginning with early application of natural amniotic membrane obtained from labor and delivery to various types of burns and wounds. 

Charles M Zelen, Thomas E Serena, Lisa Gould, Lam Le, Marissa J Carter, Jennifer Keller & William W Li

Abstract

Advanced therapies such as bioengineered skin substitutes (BSS) and dehydrated human amnion/chorion membrane (dHACM) have been shown to promote healing of chronic diabetic ulcers. An interim analysis of data from 60 patients enrolled in a prospective, randomised, controlled, parallel group, multi-centre clinical trial showed that dHACM (EpiFix®, MiMedx Group Inc., Marietta, GA) is superior to standard wound care (SWC) and BSS (Apligraf®, Organogenesis, Inc., Canton, MA) in achieving complete wound closure within 4–6 weeks. 

Neil H Riordan, Ben A George , Troy B Chandler and Randall W McKenna

Abstract

Introduction:
 Non-healing wounds can pose a medical challenge as in the case of vasculopathic venostasis resulting in a surgical ulcer. When traditional approaches to wound care fail, an amniotic patch (a dehydrated tissue allograft derived from human amnion) can function as a biologic scaffold to facilitate and enhance tissue regeneration and rehabilitation.